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In spite of being associated with SARMS, Stenabolic (SR9009) is in fact a Rev-ErbA ligand. It means SR binds to this protein and makes it more active. As a result, the user will experience a lot of positive effects, such as increased fat loss, enhanced endurance, and many other health benefits. Interestingly, it is one of the newest advances in pharmacology, but it is already getting more and more popularity among athletes all over the world.
By stimulating the Rev-Erb protein, SR9009 has the ability to greatly influence a lot of regulatory mechanisms in the human body. For instance, it can affect the circadian rhythms, lipid and glucose metabolism, fat-storing cells, as well as macrophages. Hence, Stenabolic will allow the user to lose fat and drastically increase endurance, both of which are very desirable effects for an athlete.
By binding and activating the Rev-Erb protein, Stenabolic triggers a very wide range of processes in the body. The most prominent being the increase of mitochondria count in the muscles and an enhanced metabolism.
As a consequence of the increased number of mitochondria in the muscles, the user will notice a drastic improvement in endurance and muscle strength. In fact, the mice used in studies could run 50% more when they were administered with SR9009, both in terms of distance and time. This is possible due to the fact that these mitochondria are precisely the ones generating energy in the body. Besides, thanks to the increase in number of macrophages, defective mitochondria are removed from the muscles and replaced with new ones.
Furthermore, the change in metabolic rates increases energy expenditure by 5% even when the user is resting; hence, SR burns excess calories and doesn’t allow them to convert into fat. This, coupled with enhanced metabolism of glucose, helps effectively burn fat, which makes the body act is if it were in a constant state of exercise. To confirm this, we can see that according to studies, the activation of the Rev-Erb protein by Stenabolic leads to:
“…decreased lipogenesis and cholesterol/bile acid synthesis in the liver, increased lipid and glucose oxidation in the skeletal muscle, and decreased triglyceride synthesis and storage in the WAT.”
This means that less fat is stored, less cholesterol is developed by the liver, and more fat and glucose is burned in the muscles.
However, these are not the only positive health effects seen with stenabolic. In fact, in the studies carried out with this compound it was found that it will decrease:
Plasma triglycerides by 12%
Total cholesterol by 47%
Plasma non-esterified fatty acids by 23%
Plasma glucose by 19%
Plasma insulin level by 35%
If that wasn’t enough, we need to mention that SR9009 will also decrease proinflammatory cytokine IL-6 by a whopping 72%, which will obviously be very beneficial for the reduction of inflammations.
The optimal dosages range from 20 to 30 milligrams (mgs) per day. However, there is one drawback – due to a very short half life, you will need to space it out throughout the day for the best balance of the active substance in the body. Thus, it is best to use stenabolic every 2-4 hours, depending on the exact dosage used. For example, when the daily dosage is 30 mgs, you can take 10 mgs every 4 hours.
Up to now, no side effects have been observed with SR9009, so it may be seen as an extremely safe compound. Since Stenabolic is not a hormonal drug, it does not aromatize into estrogen and there is no suppression of natural testosterone production. Moreover, just like in the case of other SARMS, SR9009 is not liver toxic, but there is a need for liver supporting supplements when using it.
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